Cyclodehydratases
WebRibosomally synthesized and post-translationally modified peptides (RiPPs) are peptide-derived natural products that include the FDA-approved analgesic ziconotide1,2 as well as compounds with... WebThiazoles and oxazoles are installed by the successive action of an ATP-dependent cyclodehydratase (C- and D-protein) and a FMN-dependent dehydrogenase (B-protein), …
Cyclodehydratases
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WebThe oxidation (dehydrogenation) of thiazoline to thiazole is common in natural products, especially in RiPPs. 543, 546 The tendency for RiPP BGCs to install thiazoles may … WebF protein-dependent cyclodehydratase Recent work from our group 36 has revealed the dependence of truncated cyclodehydratases found in thiopeptide 3 and heterocycloanthracin (Hca) gene clusters 35 on a newly recognized biosynthetic protein (TOMM F protein).
WebJul 10, 2024 · Cyclodehydratases are a type of RiPP modifying enzyme that catalyze phosphorylation of the peptide backbone and subsequent nucleophilic attack by … WebJun 6, 2015 · ( A) A model for cyclodehydration in clusters containing an N-terminally truncated fused cyclodehydratase and a TOMM F protein is displayed. ( B) A …
WebFeb 27, 2009 · As exemplified by phylogenetic analysis of the thiopeptide cyclodehydratases, they are distinct from the polythiazole synthetases in both bacteriocin and cyanobactin biosynthesis ( Li et al., 1996, Donia et al., 2006, Lee et al., 2008, Walsh and Nolan, 2008) ( Figure S3 ). WebCyclodehydration of alditolyl chains of pyrrol-2-yl acyclo C-nucleosides or their partially O-protected derivatives by heating in vacuum [50AQ(B)73], by heating in acid solutions …
WebCyclodehydratases and dehydrogenases represent an exceptionally well-studied class of RiPP enzymes. 3 These enzymes work together to catalyze intramolecular cyclization 3,4 and subsequent...
WebJun 17, 2010 · Recently, the importance of cyclodehydratases in the production of therapeutics has been emphasized by the independent discovery by several groups that … screen lag on projector macWebDaniel BRAUER, PhD Candidate Cited by 244 of University of California, Berkeley, CA (UCB) Read 22 publications Contact Daniel BRAUER screenklean tablet screen cleanerWebTo investigate whether YcaO cyclodehydratases precisely recognize the common structural characteristics and chirality of the modifiable residues, the “reprogrammed FIT … screen labs recorderWebApr 17, 2015 · Class II enzymes are generically named LanMs, which are single polypeptides containing an N-terminal dehydratase domain that bears no homology to any functionally known enzymes and a C-terminal LanC-like cyclase domain ( 13, 14 ). Class III and class IV synthetases are trifunctional enzymes termed LanKC ( 15) and LanL ( 16 ), … screenland ministryWebCyclodehydratases and dehydrogenases represent an exceptionally well-studied class of RiPP enzymes. 3 These enzymes work together to catalyze intramolecular cyclization … screenland literary associatesWebAnti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment by Sergey Zotchev 15 Biology , Fungi , Medicine , Multidisciplinary Utilization of n-alkanes by a newly isolated strain of Acinetobacter venetianus: the role of two AlkB-type alkane hydroxylases screenland consoleCarbohydrase is the name of a set of enzymes that catalyze 5 types of reactions, turning carbohydrates into simple sugars, from the large family of glycosidases. Carbohydrases are produced in the pancreas, salivary glands and small intestine, breaking down polysaccharides. This is because complex sugars are often insoluble (such as starch), and therefore breaking them down will make it easier for the sugars to be absorbed into the blood, t… screen lamination