Web22 giu 2011 · The HLA-B44 supertype, analyzed by Hillen et al. (2008) is somewhat an “exception” among other supertypes: while 74% of the B44-ligands reported in IEDB exhibit promiscuous binding, across supertypes promiscuity is much lower at 17% (Table 2). Web9 dic 2024 · HLA-A*03 is a predictive biomarker of poor response to ICI. Further evaluation of HLA-A*03 is warranted in randomised trials. HLA-A*03 carriage could be considered in decisions to initiate ICI in patients with cancer.
HLAsupE: an integrated database of HLA supertype …
Web15 gen 2007 · As noted above, the definition of supertypes is based on identifying HLA molecules that bind to sets of overlapping peptides. This definition implies that the distances between binding peptides can be naturally used to define a … Web14 ott 2004 · Several of these HLA supertypes have not yet been described at the structural level. To support a comprehensive understanding of human immune responses, the structure of at least one member of each supertype should be determined. Here, the structures of two immunogenic peptide-HLA-B*1501 complexes are described. dr allen thompson
Human leukocyte antigen supertype matching after …
WebSeven different supertypes (main DR, DR4, DRB3, main DQ, DQ7, main DP, and DP2) were defined. The molecules associated with the respective supertypes fell largely along lines defined by MHC locus and reflect, in broad terms, commonalities in … Web16 giu 2016 · The latest version of the database maintains 17,889 unique records of HLA supertype-specific epitopes (SupEs) and 107,747 records of HLA supertype-specific … Web16 dic 2024 · In this issue of Nature Cancer, Cummings et al. report their investigation 9 of the cause of conflicting reports that patients carrying the HLA-B44 supertype had better responses to ICB in ... dr. allen towfigh new york city