WebFluorescently labeled K562 cells expressing hLAIR-1 were allowed to interact for 3 h. Percentage of adhering cells relative to the input signal is shown. Cells did not adhere to … Web1 mag 2009 · Notably, of these hLAIR-2-binding peptides, II-42 and II-49 and peptide III-5, did not show adhesion of hLAIR-1-transfected cells, but did induce GFP expression in hLAIR-1-CD3ζ-expressing reporter cells, supporting the latter possibility (Fig. 1, Fig. 2). Similarly, hLAIR-2 bound quite well to CRP, a relatively poor ligand for LAIR-1.
HLAIR - What does HLAIR stand for? The Free Dictionary
Web17 set 2024 · In the 2B4 NFAT–GFP reporter cell lines, extracellular domains of human leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) and SIRL-1 are fused to … WebWhole blood was stained with either Purified Mouse Anti-Human LAIR-1 (CD305) (Cat. No. 550810; solid line histogram) or Purified Mouse IgG1, κ Isotype Control (Cat. No. 555746; dashed line histogram) followed by FITC Goat Anti-Mouse IgG/IgM (Cat. No. 555988). Erythrocytes were lysed with Pharm Lyse™ Lysing Buffer (Cat. No. 555899). region iv administrator allen thomas
Cancer immunotherapy based on blocking immune suppression …
Web1 ott 2011 · We tested the capacity of human (hLAIR-1) and mouse (mLAIR-1) LAIR-1-Fc fusion proteins to bind tumor-cell expressed collagens on a panel of adherent cancer cell lines, for comparison we used two untransformed cell lines. hLAIR-1 and mLAIR-1 bound to surface ligands on most of the cancer cell lines tested whereas untransformed lines had … Web5 giu 2006 · Binding of hLAIR-1–IgG and mLAIR-1–IgG to hcollagen XVII was blocked by anti–hLAIR-1 antibodies (8A8) or polyclonal anti–mLAIR-1 antibodies, respectively, demonstrating the specificity of these interactions (Fig. 1, B and C). The association was divalent cation independent; EDTA did not affect LAIR-1 fusion protein binding (not … Web1 dic 2011 · Human leukocyte-associated immunoglobulin-like receptor 1 (hLAIR-1) is an immune inhibitory receptor for collagen that is expressed on most immune cells. We previously showed that the LAIR-1-collagen interaction could be antagonized by the secreted homolog hLAIR-2, which can be detected in the synovial fluid of rheumatoid … problems with invariance testing