Irf7 macrophage
WebDec 15, 2024 · Overexpression of IRF7 or miR-1587 knockdown reversed M2 macrophage-induced cell proliferation and migration as well as tumor growth in vivo. Mechanistically, miR-1587 targeted the 3ʹ-untranslated region (3ʹ-UTR) of IRF7 mRNA to regulate its protein expression leading to tumor progression. WebOverexpression of IRF7 resulted in enhanced viral replication while knocking down IRF7 expression in macrophages significantly reduced viral output. These findings are the first demonstration that ...
Irf7 macrophage
Did you know?
WebDec 23, 2011 · IRF7-KO mice (n = 7) had more infiltrating CD45 high CD11b + macrophages (D), CD4+ (E) and CD8+ (F) cells in the CNS compared to WT mice (n = 6). Full size image IRF7 deficiency affected distribution of infiltrating immune cells in CNS WebApr 14, 2011 · IRF7 is a lymphoid-specific factor, which is constitutively expressed in the cytoplasm in B cells, pDCs and monocytes in the spleen, thymus, and peripheral blood lymphocytes, and is potently...
WebJul 21, 2024 · This gene expression analysis indicates that PU.1, C/EBPβ, and IRF7 could be directing Pam 3 CSK 4 -induced macrophage differentiation. Therefore, we examined the expression of these transcription factor genes that are induced downstream of TLR2 signaling and may be involved in myeloid differentiation by quantitative real-time PCR. WebSep 10, 2024 · SeV-induced IRF7 expression in macrophages was accompanied with two weak upshifted bands: one at around 60 kDa and another at the position similar to …
WebIRF3 and IRF7 were altered in 5% and 6% of all TCGA STAD patients. Further analysis revealed that IRF7 was significantly associated with the abundance of immune cells (B cells, Neutrophils and Dendritic cells) and the expression of most immune biomarkers. Enrichment analysis indicated that IRF7 was mainly involved in adaptive immune response ... WebAug 5, 2013 · Current data suggest that the family of the interferon-regulatory factors (IRFs) plays an important role in regulating macrophage polarization. IRFs are intracellular proteins that regulate immune cell maturation [19].
WebInterferon regulatory receptor 7 (IRF7) is a transcription factor involved in the activation of the type I interferon (IFN) response upon pathogenic infection [3-4]. IRF7 has been …
WebApr 21, 2024 · JEV infection resulted in M-MDSC infiltration into the CNS, and the infiltrated M-MDSCs later differentiated into CD3 + macrophages. RNA-seq data and in vitro experiments indicated that the ZBP1-IRF7 signaling pathway plays an important role in JEV-induced M-MDSC generation. jyjジュンス 兄WebNov 6, 2024 · SiRNA-mediated inhibition of IRF7 reduces HIV-1 Tat-induced modulation of interferon (IFN)-stimulated genes in immature dendritic cells and in monocyte-derived macrophages: PubMed: tat: HIV-1 Tat-mediated downregulation of TRAF3 increases levels of phosphorylation of IRF3 and IRF7 in human microglial cells: PubMed: Vpr: vpr advance directive ti ng vi tWebMar 9, 2024 · studies suggest that expression of the IFN-alpha/beta receptor on macrophages/neutrophils and dendritic cells, as well as of IRF-3 and IRF-7, is critical for innate immune responses to NoV infection IRF7 regulates TLR2-mediated activation of splenic CD11c(hi) dendritic cells jykys ミニチュアWebMar 6, 2024 · Macrophages are immune cells that form the first line of defense against pathogens, but also mediate tissue damage in inflammatory disease. Macrophages initiate inflammation by recognising and responding to components of bacterial cells. Macrophages of the wall of the gut are constantly replenished from the blood. jyl50音順カタカナ練習帳WebDec 26, 2024 · Furthermore, IRF7 contributed to M1 characteristics through the activation of SAPK/JNK pathway. Moreover, targeting IRF7-SAPK/JNK pathway to induce M1 characteristics in LAMs contributed to prolonged survival in leukemia mice. Our study provides the potential target for macrophage based immuno-therapy strategy against … jyj 東京ドーム dvdWebIFI207 engages with IRF7 and co-localizes with active RNA polymerase II • Klebsiella requires IFI207 for macrophage entry and to establish a lung infection Summary PYHIN proteins AIM2 and IFI204 sense pathogen DNA, while other PYHINs have been shown to regulate host gene expression through as-yet unclear mechanisms. jyobi ログインWebJul 9, 2024 · In bone marrow-derived macrophages (BMDMs), RAGE ligands upregulated expression of Irf7, and in BMDMs immersed in a cholesterol-rich environment, knockdown of Irf7 triggered a switch from pro- to antiinflammatory gene expression and regulated a host of genes linked to cholesterol efflux and homeostasis. advance directive notice